NACIVTNano Aerosol Chamber In-Vitro Toxicity

Effects of inhaled nanoparticles to normal and diseased airway epithelia by in vitro technology





Delaval MN. Jonsdottir HR, Leni Z, Keller A, Brem BT, Siegerist F, Schonenberger D, Durdina L, Elser M, Salathe M, Baumlin N, Lobo P, Burtscher H, Liati A, Geiser M. Responses of reconstituted human bronchial epithelia from normal and health-compromised donors to non-volatile particulate matter emissions from an aircraft turbofan engine. Environ. Poll., 307, 119521 (2022),


Leni Z, Ess MN, Keller A, Allan JD, Hellén H, Saarnio K, Williams K, Brown A, Salathe M, Baumlin N, Vasilatou K, Geiser M. Role of secondary organic matter on soot Particle toxicity in reconstituted human bronchial epithelia exposed at the air-liquid interface. Environ. Sci. Technol. (2022), 56, 23, 17007–17017,


Jonsdottir HR, Delaval M, Leni Z, Keller A, Brem BT, Siegerist F, Schönenberger D, Durdina L, Elser M, Burtscher H, Liati A, Geiser M. Non-volatile particle emissions from aircraft turbine engines at ground-idle induce oxidative stress in bronchial cells. Nature Commun. Biol., 2:90 (2019),


Ding J, Guo J, Wang L, Chen Y, Hu B, Li Y, Huang RJ, Cao J, Zhao Y, Geiser M, Miao QR, Liu Y, Chen C. Cellular Responses to Exposure to Outdoor Air from the Chinese Spring Festival at the Air-Liquid Interface. Environ. Sci. Technol., 53(15):9128-9138 (2019),


Delaval M, Egli D, Schüpfer P, Benarafa C, Geiser M, Burtscher H. Novel instrument to generate representative e-cigarette vapors for physicochemical particle characterization and in-vitro toxicity. J. Aerosol Sci., 129:40-52 (2019),


Jonsdottir HR, Delaval M, Leni Z, Keller A, Brem BT, Siegerist F, Schönenberger D, Durdina L, Elser M, Burtscher H, Liati A, Geiser M. Respiratory Health Effects of Non-Volatile Particle Emissions from an Aircraft Turbine Engine. Am. J. Respir. Crit. Care Med. 197, (2018), Session A70, Conference Abstract: A2271, International Conference of the American-Thoracic-Society, San Diego, CA, MAY 18-23, 2018.


Jeannet N, Fierz M, Schneider S, Künzi L, Schmid N, Salathe M, Burtscher H, Geiser M. Acute toxicity of silver and carbon nanoaerosols on normal and cystic fibrosis human bronchial epithelial cells. Nanotoxicology (2015)
DOI: 10.3109/17435390.2015.1049233


Jeannet N, Fierz M, Kalberer M, Burtscher H, Geiser M. Nano Aerosol Chamber for In-Vitro Toxicity (NACIVT) Studies. Nanotoxicology, 9(1):34-42 (2015)
DOI: 10.3109/17435390.2014.886739



Related Papers


Cassagnes L-E, Leni Z, Håland A, Bell D, Zhu, L, Bertrand A, Baltensperger U, El Haddad I, Wisthaler A, Geiser M, Dommen J. Online monitoring of volatile organic compounds emitted from human bronchial epithelial cells as markers for oxidative stress. J. Breath Res. (2021), 15(1) 016015,


Daellenbach KR, Uzu G, Jiang J, Cassagnes L-E, Leni Z, Vlachou A, Stefenelli G, Canonaco F, Weber S, Segers A, Schaap M, Favez O, Albinet A, Aksoyoglu S, Dommen J, Baltensperger U, Geiser M, El Haddad I, Jaffrezo J-L, Prévôt ASH. Sources and chemistry of the harmful components in particulate air pollution. Nature (2020), 587, 414-419,


Leni Z, Cassagnes L-E, Daellenbach KR, El Haddad I, Vlachou A, Uzu G, Prévôt ASH, Jaffrezo J-L, Baumlin N, Salathe M, Baltensperger U, Dommen J, Geiser M. Oxidative stress-induced inflammation in susceptible airways by anthropogenic aerosol. PLoS ONE (2020), 15(11):e0233425.


Zhou J, Elser M, Huang R-J, Krapf M, Fröhlich R, Bhattu D, Stefenelli G, Zotter P, Bruns EA, Pieber SM, Ni H, Wang Q, Wang Y, Zhou Y, Chen C, Xiao M, Slowik JG, Brown S, Cassagnes L-E, Daellenbach KR, Nussbaumer T, Geiser M, Prévôt ASH, El-Haddad I, Cao J, Baltensperger U, Dommen J. Predominance of Secondary Organic Aerosol to Particle-bound Reactive Oxygen Species Activity in Fine Ambient Aerosol. Atmos. Chem. Phys. (2019), 19:14703–14720,


Künzi L, Krapf M, Daher N, Dommen J, Jeannet N, Schneider S, Platt S, Slowik JG, Baumlin N, Salathe M, Prévôt ASH, Kalberer M, Strähl C, Dümbgen L, Sioutas C, Baltensperger U, Geiser M. Toxicity of aged gasoline exhaust particles to normal and diseased airway epithelia. Nature Sci Reports, (2015)
DOI: 10.1038/srep11801


Ryser M, Künzi L, Geiser M, Frenz M, Rička J. In situ fiber-optical monitoring of cytosolic calcium in cultured tissue explants. J Biophotonics, 8(3):183-195 (2015)
DOI: 10.1002/jbio.201300089


Künzi L, Mertes P, Schneider S, Jeannet N, Menzi C, Dommen J, Baltenperger U, Prévôt ASH, Salathe M, Kalberer M, Geiser M. Responses of Lung Cells to Realistic Exposure of Primary and Aged Carbonaceous Aerosols. Atmos Environ, 68:143-150 (2013)
DOI: 10.1016/j.atmosenv.2012.11.055


Mertes P, Praplan AP, Künzi L, Dommen J, Baltensperger U, Geiser M, Weingartner E, Ricka J, Fierz M, Kalberer M. A compact and portable deposition chamber to study nanoparticles in air-exposed tissue. J Aerosol Med Pulm Drug Deliv, 26(4):228-235 (2013)
DOI: 10.1089/jamp.2012.0985


Gaschen A, Lang D, Kalberer M, Savi M, Geiser T, Gazdhar A, Lehr C-M, Bur M, Dommen J, Baltensperger U, Geiser M. Cellular responses after exposure of lung cell cultures to secondary organic aerosol particles. Environ Sci Techn 44:1424-1430 (2010)
DOI: 10.1021/es902261m


Savi M, Kalberer M, Lang D, Ryser M, Fierz M, Gaschen A, Rička J, Geiser M. A novel exposure system for the efficient and controlled deposition of aerosol particles onto cell cultures. Environ Sci Techn 42: 5667-5674 (2008)
DOI: 10.1021/es703075q


Geiser M, Lang D. In vitro replica of the inner surface of the lungs for the study of particle-cell interactions. Altex 24, 82-84 (2007)






Gute Nanoteilchen – schädliche Nanoteilchen? Hochschule für Technik FHNW. Forschungseinblicke FHNW 2015, pp. 36-41


Wenn Nanopartikel in der Lunge landen. UniPress 160, 2014.


Geiser M. New tests for nanoparticles: In vitro evolution. International Innovation EuroFocus: Health - March 2012:110-112 (2012)